Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)
نویسندگان
چکیده
منابع مشابه
Thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of doxorubicin.
A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...
متن کاملPreparation and Investigation of Poly (N-isopropylacrylamide-acrylamide) Membranes in Temperature Responsive Drug Delivery
Objective(s) Physiological changes in the body may be utilized as potential triggers for controlled drug delivery. Based on these mechanisms, stimulus-responsive drug delivery has been developed. Materials and Methods In this study, a kind of poly (N-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. Changes in swelling ratios and diameters of the membrane wer...
متن کاملPreparation of Temperature- and pH-Sensitive, Stimuli- Responsive Poly(N-isopropylacrylamide-co-methacrylic acid) Nanoparticles
The effects of the monomer ratio, surfactant, and crosslinker contents on the particle size and phase-transition behavior of the copolymer poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAAm–MAA) were investigated with Fourier transform infrared, differential scanning calorimetry, and dynamic laser scattering techniques. In addition to the thermoresponsive property of poly(N-isopropylacryl...
متن کاملTemperature sensitive poly(N-t-butylacrylamide-co-acrylamide) hydrogels: synthesis and swelling behavior
A series of temperature sensitive hydrogels was prepared by free-radical crosslinking copolymerization of N-t-butylacrylamide (TBA) and acrylamide in methanol. N,N0-methylenebis(acrylamide) was used as the crosslinker. It was shown that the swelling behavior of the hydrogels can be controlled by changing the amount of TBA units in the network chains. Hydrogels immersed in dimethylsulfoxide (DMS...
متن کاملNovel temperature-sensitive liposomes with prolonged circulation time.
Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Korean Chemical Society
سال: 2003
ISSN: 1017-2548
DOI: 10.5012/jkcs.2003.47.3.257